![\"\"](\"\/userfiles\/image\/Reward-crcuit.jpg\")
<\/p>\n<\/p>\n
In addition to exerting their effects through molecular mechanisms, these drugs intervene at various points in the brain\u2019s central reward circuit (see above diagram). <\/span><\/span><\/p>\n It is through this combination of effects on the reward circuit and on other brain structures that a drug induces the behaviors and specific subjective sensations. Because neural communication is so plastic, a new equilibrium will gradually be established that includes the psychoactive substances from the outside. It is this adaptability of the brain that causes tolerance, dependency, and withdrawal. <\/span><\/span>Dopamine is not the only molecule involved in this process of drug co-dependency. Tolerance is a mechanism that gradually reduces the effects of a drug. The adaptable brain\u2019s downside is that it drives drug addicts to increase their dosage to try to feel again the intoxicating effects felt with their first \u201cfix\u201d<\/span>. <\/span><\/span><\/p>\n The plasticity of the human brain facilitates the creation of dependencies. When chronic consumers of a certain drug suddenly stop taking it, their neurons have to learn to cope with a new biochemical environment. <\/span><\/span><\/p>\n As a result, people experience discomfort and cravings. To overcome their strong dependency, they must go through a period of withdrawal until their neurons have relearned how to function without the drug. <\/span><\/span><\/p>\n Addiction affects DNA transcription factors<\/span><\/a> like Delta-FosB<\/span><\/a> Research experiments were able to show that the gene Maged1<\/span> controls the release of dopamine in the nucleus accumbens.<\/span><\/span><\/p>\n
\n<\/span><\/span><\/p>\n
\n<\/span><\/span><\/p>\n![\"\"](\"\/userfiles\/image\/2014%20pics\/DNA-DeltaFosB.gif\")
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\nPast life Programs also determine
\nthe use of transcription factors
\nWithdrawal is needed to allow your system
\nto remove those factors<\/span><\/span><\/strong><\/span><\/p>\n