DNA Mis-Match Repair (MMR) The DNA Mis-Match Repair (MMR) pathway has evolved to correct errors made by DNA polymerase during DNA replication. Such errors fall into two broad categories: base substitutions, and insertions/deletions. 1. A base substitution error occurs when DNA polymerase inserts an incorrect nucleotide opposite the template base, like a T opposite G…
Base Excision Repair (BER) The basic steps of the BER pathway are: 1. Distortion recognition, 2. Base excision, 3. AP-site incision, 4. DNA repair synthesis, 5. DNA ligation. DNA bases that have been modified by the addition or loss of a small chemical group as described above are repaired by the BER pathway (see video…
Our nuclear DNA genome is under constant attack from reactive chemicals that the cell generates as by-products of metabolism, as well as environmental threats as X rays, UV radiation from the sun, and immense chemical pollution, etc. Missing few ‘letters’ can stop brain growth before age 30 Among the 100,000’s of mutations within the human…
The unique sequence of more than 3 Billion base-pairs in our DNA molecule is what makes each of us unique. Our DNA is like a cookbook full of ‘recipes’ and ‘bookmarks’. Different cells use different recipes, which we call ‘genes’. The bookmarks help each cell know which genes to use. These bookmarks exist as chemical…
Effects on your muscle cells’ DNA and protein production Researchers recruited 14 men and women in their mid-20s who didn’t usually exercise. After a short but intense spin on a bike, samples of their muscle tissue showed temporary, but big, changes in several types of epigenetic signals. Physical exercise sets signals in motion almost instantly…
Developments of Domiciles and Offices “Beauty is the promise of happiness” How human needs and desires manifest their ideals in architecture. 988 CPntL: my temporary ‘Heaven on Earth‘ at age 40 26 Residential sub-division with individual boatslips, named “Neptune’s Landing”, to “enable the Planetary Neptune to re-enter and re-claim, as Poseidon, the shores of this…
Researching micro cluster water and Magnetic Resonance Analysis technology, Dr. Masaru Emoto demonstrated that human thoughts and emotions could alter the molecular structure and crystalline forms of water. He found that water from clear –telluric current– springs and water that has been exposed to loving words shows brilliant, complex, colorful, symmetrical, and hexagonal snowflake patterns….
Just the tiny visible part of our cosmos contains over 2 Trillion galaxies; each galaxy containing 200–1.000 billion stars: Galaxies interacting with each other Two galaxies beginning to interweave Black hole with 6 galaxies trapped in its gravity well van Gogh “Starry Night”, and the Math of turbulent flow Galactic magnetic fields throughout the Milky…
The Gospel of Peter has several intriguing features. These include a similarity to the 4 canonical gospels, a distinct anti-Judaism, its suppression by the early church, and its potentially docetic character. The latter aspect, docetism , assumes that if the Cosmic-Christ was truly divine he could not be human, and thus he could not actually…
Quantum Physicists believe there are around 233 different particles with names such as quarks, photons, electrons, muons, bosons, fermions, hadrons, etc., and their different spin directions, electrical charges, mass, that are present in the electro-magnetic-, weak-, strong-, and gravity-force. Our New Jerusalem model below contains: All 5 Platonic Solids + Icosa-Dodecahedron. The model below has…
In order to better understand the basic ingredients and the ‘cooking conditions’ of the cosmos, from cosmic day one till today, particle physicists are trying to reverse-engineer the ‘universal soup’. Within this complex concoction, cryptic clues hide the instructions for the cosmic recipe. Both stars and humans are made of the same type of atoms,…
The strangest consequences of quantum mechanics had only been seen at the atomic and molecular levels. Recent experiments, however, showed quantum superpositions in much larger ‘superconducting quantum interference devices’ (SQUID’s for short). This has raised the extraordinary possibility of ‘Schrodinger’s Cat’ states (this refers to Schrodinger’s remark that quantum mechanics in principle allowed a Cat…
